|
KMID : 1007520130220030811
|
|
Food Science and Biotechnology
2013 Volume.22 No. 3 p.811 ~ p.815
|
|
|
Japanese Bog Orchid (Eupatorium japonicum) Extract Suppresses Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Induced by Toll-like Receptor Agonists
|
|
Gu Gyo-Jeong
Eom Sang-Hoon
Shin Hwa-Jeong
Paek Ji-Hun
Kim Song-Mun
Lim Soon-Sung
Youn Hyung-Sun
|
|
|
Abstract
|
|
|
|
Toll-like receptors (TLR) play an important role in the recognition of many pathogen-associated molecular patterns and the induction of innate immunity. Dysregulated activation of TLR signaling pathways is associated with certain inflammatory diseases. Japanese bog orchid (Eupatorium japonicum), which belongs to a family of Asteraceae plants, is consumed as a tea. The present study investigated the effect of the ethanol extracts of flowers of Japanese bog orchid (EJE) on nuclear factor (NF)-κB activation and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by TLR agonists in murine macrophages. EJE suppressed NF-κB activation and iNOS and COX-2 expression induced by lipopolysaccharide (TLR4 agonist), polyriboinosinic polyribocytidylic acid (TLR3), and macrophage-activating 2 kDa lipopeptide (TLR2 and TLR6). These results suggest that EJE can regulate TLR signaling pathways and indicated its potential as a potent anti-inflammatory drug.
|
|
|
KEYWORD
|
|
|
Eupatorium japonicum, inflammation, nuclear factor-κB, cyclooxygenase-2, inducible nitric oxide synthase
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|